Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50249141 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_499971 (CHEMBL1019341) | ||
| EC50 | >5000±n/a nM | ||
| Citation |  Yang, BV; Vaccaro, W; Doweyko, AM; Doweyko, LM; Huynh, T; Tortolani, D; Nadler, SG; McKay, L; Somerville, J; Holloway, DA; Habte, S; Weinstein, DS; Barrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50249141 | |||
| n/a | |||
| Name | BDBM50249141 | ||
| Synonyms: | 15-methyl-N-(4-methyl-1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL472800 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H20N2OS | ||
| Mol. Mass. | 360.472 | ||
| SMILES | Cc1csc(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc32)n1 |TLB:9:8:12.17:19.24,16:17:10.8:19.24,20:19:12.17:10.8,THB:6:8:12.17:19.24,(25.89,-10.69,;24.49,-11.33,;23.15,-10.57,;22.01,-11.62,;22.65,-13.02,;21.9,-14.37,;20.35,-14.38,;19.57,-13.06,;19.6,-15.72,;18.25,-14.95,;20.11,-16.49,;20.11,-18.68,;18.25,-19.2,;16.9,-19.97,;15.57,-19.2,;15.57,-17.66,;16.9,-16.88,;18.21,-17.81,;19.6,-17.14,;21.13,-18.03,;22.4,-17.3,;23.68,-18.03,;23.69,-19.51,;22.41,-20.25,;21.13,-19.51,;24.19,-12.84,)| | ||
| Structure | 
| ||