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TargetGlucocorticoid receptor
LigandBDBM50249109
Substrate/Competitorn/a
Meas. Tech.ChEMBL_499975 (CHEMBL1022034)
EC50>10000±n/a nM
Citation Yang, BVVaccaro, WDoweyko, AMDoweyko, LMHuynh, TTortolani, DNadler, SGMcKay, LSomerville, JHolloway, DAHabte, SWeinstein, DSBarrish, JC Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. Bioorg Med Chem Lett19:2139-43 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glucocorticoid receptor
Name:Glucocorticoid receptor
Synonyms:GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1
Type:Enzyme
Mol. Mass.:85656.87
Organism:Homo sapiens (Human)
Description:P04150
Residue:777
Sequence:
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
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  Blast E-value cutoff:
BDBM50249109
n/a
NameBDBM50249109
Synonyms:15-methyl-1-nitro-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2.0^{2,7}.0^{9,14}]hexadeca-2,4,6,9(14),10,12-hexaene-15-carboxamide | CHEMBL514481
TypeSmall organic molecule
Emp. Form.C21H17N3O3S
Mol. Mass.391.443
SMILESCC1(CC2c3ccccc3C1(c1ccccc21)[N+]([O-])=O)C(=O)Nc1nccs1 |TLB:12:11:4.9:2.1,8:9:2.1:11.16,THB:20:1:4.9:11.16,0:1:4.9:11.16,(34.68,-16.56,;33.21,-16.97,;33.72,-17.74,;33.72,-19.93,;31.85,-20.45,;30.51,-21.22,;29.17,-20.45,;29.18,-18.9,;30.5,-18.13,;31.82,-19.05,;33.21,-18.39,;34.74,-19.28,;36.02,-18.54,;37.3,-19.27,;37.3,-20.76,;36.02,-21.5,;34.74,-20.76,;31.86,-17.61,;32.63,-16.27,;30.32,-17.61,;33.96,-15.63,;33.18,-14.3,;35.51,-15.61,;36.26,-14.26,;37.8,-14.08,;38.11,-12.57,;36.76,-11.81,;35.63,-12.86,)|
Structure
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