Reaction Details |
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Target | Melatonin receptor type 1B |
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Ligand | BDBM50316700 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_632479 (CHEMBL1108343) |
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EC50 | >10000±n/a nM |
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Citation | Mésangeau, C; Pérès, B; Descamps-François, C; Chavatte, P; Audinot, V; Coumailleau, S; Boutin, JA; Delagrange, P; Bennejean, C; Renard, P; Caignard, DH; Berthelot, P; Yous, S Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem18:3426-36 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1B |
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Name: | Melatonin receptor type 1B |
Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
Type: | Enzyme |
Mol. Mass.: | 40203.54 |
Organism: | Homo sapiens (Human) |
Description: | P49286 |
Residue: | 362 |
Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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BDBM50316700 |
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n/a |
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Name | BDBM50316700 |
Synonyms: | CHEMBL1095832 | N-[2-(7-{4-[8-(2-Cyclopropanecarbonylaminoethyl)naphthalen-2-yloxy]butoxy}naphthalen-1-yl)ethyl]acetamide |
Type | Small organic molecule |
Emp. Form. | C34H38N2O4 |
Mol. Mass. | 538.6765 |
SMILES | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12 |
Structure |
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