| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Ligand | BDBM50320777 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_639163 (CHEMBL1167424) |
|---|
| IC50 | 8300±n/a nM |
|---|
| Citation |  Maccari, R; Ciurleo, R; Giglio, M; Cappiello, M; Moschini, R; Corso, AD; Mura, U; Ottanà, R Identification of new non-carboxylic acid containing inhibitors of aldose reductase. Bioorg Med Chem18:4049-55 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Name: | Aldo-keto reductase family 1 member B1 [K65Q] |
|---|
| Synonyms: | AKR1B1 | ALDR_BOVIN | Aldose reductase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35916.27 |
|---|
| Organism: | Bos taurus (Cattle) |
|---|
| Description: | P16116[K65Q] |
|---|
| Residue: | 315 |
|---|
| Sequence: | AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
|
|
|
|---|
| BDBM50320777 |
|---|
| n/a |
|---|
| Name | BDBM50320777 |
|---|
| Synonyms: | (Z)-5-[(4-Phenoxyphenyl)methylidene]-3-(3,3,3-trifluoro-2-oxopropyl)-2,4-thiazolidinedione | CHEMBL1164765 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H12F3NO4S |
|---|
| Mol. Mass. | 407.363 |
|---|
| SMILES | FC(F)(F)C(=O)CN1C(=O)S\C(=C/c2ccc(Oc3ccccc3)cc2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
