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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-secretase 1 | ||
| Ligand | BDBM50323211 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_643854 (CHEMBL1211753) | ||
| IC50 | 350±n/a nM | ||
| Citation |  Sasaki, H; Miki, K; Kinoshita, K; Koyama, K; Juliawaty, LD; Achmad, SA; Hakim, EH; Kaneda, M; Takahashi, K beta-Secretase (BACE-1) inhibitory effect of biflavonoids. Bioorg Med Chem Lett20:4558-60 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-secretase 1 | |||
| Name: | Beta-secretase 1 | ||
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 55755.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P56817 | ||
| Residue: | 501 | ||
| Sequence: |
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| BDBM50323211 | |||
| n/a | |||
| Name | BDBM50323211 | ||
| Synonyms: | 2,3-dihydro-6-methylginkgetin | CHEMBL1208905 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H26O10 | ||
| Mol. Mass. | 582.5535 | ||
| SMILES | COc1cc2O[C@@H](CC(=O)c2c(O)c1C)c1ccc(OC)c(c1)-c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1 |r,wD:6.16,(21.01,-13.22,;19.68,-13.99,;19.68,-15.53,;21.02,-16.29,;21.03,-17.84,;22.36,-18.61,;22.37,-20.15,;21.02,-20.94,;19.68,-20.16,;18.34,-20.93,;19.68,-18.61,;18.35,-17.84,;17.02,-18.61,;18.35,-16.3,;17.02,-15.53,;23.7,-20.92,;25.03,-20.14,;26.35,-20.91,;26.36,-22.45,;27.7,-23.21,;29.03,-22.44,;25.03,-23.22,;23.7,-22.46,;25.04,-24.75,;23.7,-25.53,;22.37,-24.75,;23.71,-27.06,;25.04,-27.83,;25.03,-29.37,;26.37,-27.05,;26.36,-25.52,;27.68,-24.74,;29.02,-25.5,;29.02,-27.04,;27.7,-27.8,;27.69,-29.34,;30.34,-24.73,;31.68,-25.5,;33.01,-24.72,;33.01,-23.18,;34.34,-22.4,;31.66,-22.42,;30.34,-23.19,)| | ||
| Structure | 
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