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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Beta-secretase 1 | ||
| Ligand | BDBM50323201 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_643854 (CHEMBL1211753) | ||
| IC50 | 4210±n/a nM | ||
| Citation |  Sasaki, H; Miki, K; Kinoshita, K; Koyama, K; Juliawaty, LD; Achmad, SA; Hakim, EH; Kaneda, M; Takahashi, K beta-Secretase (BACE-1) inhibitory effect of biflavonoids. Bioorg Med Chem Lett20:4558-60 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Beta-secretase 1 | |||
| Name: | Beta-secretase 1 | ||
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 55755.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P56817 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| BDBM50323201 | |||
| n/a | |||
| Name | BDBM50323201 | ||
| Synonyms: | CHEMBL144630 | podocarpusflavone B | putraflavone | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H22O10 | ||
| Mol. Mass. | 566.5111 | ||
| SMILES | COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(OC)cc4=O)o3)c2o1 |(24.55,-16.67,;23.22,-17.45,;21.88,-16.69,;21.86,-15.15,;20.52,-14.39,;19.19,-15.18,;19.21,-16.72,;20.55,-17.48,;17.85,-14.43,;17.84,-12.89,;16.5,-12.13,;16.48,-10.59,;15.17,-12.91,;13.83,-12.16,;13.81,-10.61,;12.5,-12.94,;12.52,-14.48,;11.19,-15.26,;13.86,-15.24,;13.88,-16.78,;12.55,-17.56,;12.57,-19.1,;13.91,-19.86,;15.24,-19.07,;15.22,-17.53,;16.54,-16.75,;11.24,-19.88,;9.9,-19.13,;8.57,-19.91,;7.24,-19.16,;8.59,-21.45,;9.93,-22.21,;9.95,-23.75,;8.62,-24.53,;8.64,-26.08,;7.32,-26.86,;7.28,-23.78,;7.26,-22.23,;5.92,-21.48,;11.26,-21.43,;15.19,-14.46,;16.53,-15.21,)| | ||
| Structure | 
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