| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50304619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675275 (CHEMBL1273257) |
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| Ki | 0.5±n/a nM |
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| Citation |  Pinto, DJ; Smallheer, JM; Cheney, DL; Knabb, RM; Wexler, RR Factor Xa inhibitors: next-generation antithrombotic agents. J Med Chem53:6243-74 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50304619 |
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| n/a |
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| Name | BDBM50304619 |
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| Synonyms: | (S)-2-(1-(3-(6-chloronaphthalen-2-ylsulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)-5-methyl-1H-imidazo[1,5-c]imidazol-3(2H)-one | 2-(1-{(2S)-3-[(6-Chloronaphthalene-2-yl)sulfonyl]-2-hydroxypropanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3Himidazo[1,5-c]imidazol-3-one | CHEMBL593461 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClN4O5S |
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| Mol. Mass. | 516.997 |
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| SMILES | Cc1ncc2CN(C3CCN(CC3)C(=O)[C@H](O)CS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C(=O)n12 |r| |
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| Structure | 
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