| Reaction Details |
|---|
 | Report a problem with these data |
| Target | D(3) dopamine receptor |
|---|
| Ligand | BDBM50336862 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_718443 (CHEMBL1680107) |
|---|
| Ki | 240±n/a nM |
|---|
| Citation |  Sromek, AW; Si, YG; Zhang, T; George, SR; Seeman, P; Neumeyer, JL Synthesis and Biological Evaluation of N-Fluoroalkyl and 2-Fluoroalkoxy Substituted Aporphines: Potential PET Ligands for Dopamine D(2) Receptors. ACS Med Chem Lett2:189-194 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| D(3) dopamine receptor |
|---|
| Name: | D(3) dopamine receptor |
|---|
| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 49540.58 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P19020 |
|---|
| Residue: | 446 |
|---|
| Sequence: | MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
|
|
|
|---|
| BDBM50336862 |
|---|
| n/a |
|---|
| Name | BDBM50336862 |
|---|
| Synonyms: | CHEMBL1672311 | N-ethyl-2-fluoropropanoxy-11-monohydroxy aporphine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24FNO2 |
|---|
| Mol. Mass. | 341.4192 |
|---|
| SMILES | CCN1CCc2cc(OCCCF)cc-3c2[C@H]1Cc1cccc(O)c-31 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
