Ki Summary

Reaction Details

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Target

Calmodulin-domain protein kinase 1

Ligand

BDBM50345706

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_750529 (CHEMBL1786290)

IC50

460±n/a nM

Citation

Murphy, RC; Ojo, KK; Larson, ET; Castellanos-Gonzalez, A; Perera, BG; Keyloun, KR; Kim, JE; Bhandari, JG; Muller, NR; Verlinde, CL; White, AC; Merritt, EA; Van Voorhis, WC; Maly, DJ Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. ACS Med Chem Lett1:331-335 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calmodulin-domain protein kinase 1

Name:

Calmodulin-domain protein kinase 1

Synonyms:

Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57248.42

Organism:

Toxoplasma gondii

Description:

n/a

Residue:

507

Sequence:

MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN

BDBM50345706

n/a

Name

BDBM50345706

Synonyms:

1-methyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1784959 | US10544104, Compound 5a | US11247972, Compound 5a | US9765037, Compound 5a

Type

Small organic molecule

Emp. Form.

C17H15N5

Mol. Mass.

289.3345

SMILES

Cn1nc(Cc2cccc3ccccc23)c2c(N)ncnc12

Structure