| Reaction Details |
|---|
 | Report a problem with these data |
| Target | B1 bradykinin receptor |
|---|
| Ligand | BDBM50381265 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_814371 (CHEMBL2019580) |
|---|
| IC50 | 21±n/a nM |
|---|
| Citation |  Eles, J; Beke, G; Vágó, I; Bozó, E; Huszár, J; Tarcsay, A; Kolok, S; Schmidt, E; Vastag, M; Hornok, K; Farkas, S; Domány, G; Keseru, GM Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists. Bioorg Med Chem Lett22:3095-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| B1 bradykinin receptor |
|---|
| Name: | B1 bradykinin receptor |
|---|
| Synonyms: | B1 BRADYKININ | B1R | B1bkr | BK-1 receptor | BKRB1_RAT | Bdkrb1 | Bkr | Bradykinin B1 receptor | KB1 | Kinin B1 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38389.97 |
|---|
| Organism: | RAT |
|---|
| Description: | B1 BRADYKININ BDKRB1 RAT::P97583 |
|---|
| Residue: | 337 |
|---|
| Sequence: | MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSF
FLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLC
RVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSI
PTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLR
GQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEIT
DLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL
|
|
|
|---|
| BDBM50381265 |
|---|
| n/a |
|---|
| Name | BDBM50381265 |
|---|
| Synonyms: | CHEMBL2018873 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H30Cl2N4O4S |
|---|
| Mol. Mass. | 649.587 |
|---|
| SMILES | COc1cccc2C(CC(=O)NCCc3ccc(cc3)C3=NCCN3)N(c3ccccc3-c12)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
