Reaction Details |
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Target | C-C chemokine receptor type 3 |
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Ligand | BDBM50394123 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_856369 (CHEMBL2160724) |
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Ki | 19.95±n/a nM |
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Citation | Bahl, A; Barton, P; Bowers, K; Caffrey, MV; Denton, R; Gilmour, P; Hawley, S; Linannen, T; Luckhurst, CA; Mochel, T; Perry, MW; Riley, RJ; Roe, E; Springthorpe, B; Stein, L; Webborn, P Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092. Bioorg Med Chem Lett22:6694-9 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 3 |
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Name: | C-C chemokine receptor type 3 |
Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
Type: | Enzyme |
Mol. Mass.: | 41053.88 |
Organism: | Homo sapiens (Human) |
Description: | P51677 |
Residue: | 355 |
Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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BDBM50394123 |
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n/a |
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Name | BDBM50394123 |
Synonyms: | CHEMBL2158777 |
Type | Small organic molecule |
Emp. Form. | C27H31Cl2F3N2O3 |
Mol. Mass. | 559.448 |
SMILES | OC(=O)[C@H](Cc1cccc(c1)C(F)(F)F)N1CCC(CN2CCC(CC2)Oc2ccc(Cl)c(Cl)c2)CC1 |r| |
Structure |
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