| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM50132435 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_861813 (CHEMBL2173406) |
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| EC50 | 3500±n/a nM |
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| Citation |  Singh, R; Masuda, ES; Payan, DG Discovery and development of spleen tyrosine kinase (SYK) inhibitors. J Med Chem55:3614-43 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_RAT | Syk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71541.93 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1348392 |
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| Residue: | 629 |
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| Sequence: | MAGNAVDNANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPVTWSPGGIISRIKSYSFPKPGHKKP
PPPQGSRPESTVSFNPYEPTGGAWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RKLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAAWGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
FKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMF
LCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM50132435 |
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| n/a |
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| Name | BDBM50132435 |
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| Synonyms: | 3-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)-2-oxoindoline-5-carboxylic acid | 3-[1-(5-Methoxy-1-methyl-1H-indol-3-yl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid | CHEMBL104813 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N2O4 |
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| Mol. Mass. | 348.352 |
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| SMILES | COc1ccc2n(C)cc(\C=C3/C(=O)Nc4ccc(cc34)C(O)=O)c2c1 |
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| Structure | 
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