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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50396358
Substrate/Competitorn/a
Meas. Tech.ChEMBL_861906 (CHEMBL2173634)
Ki 741±n/a nM
Citation Díaz, JLCuberes, RBerrocal, JContijoch, MChristmann, UFernández, APort, AHolenz, JBuschmann, HLaggner, CSerafini, MTBurgueño, JZamanillo, DMerlos, MVela, JMAlmansa, C Synthesis and biological evaluation of the 1-arylpyrazole class ofs(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem55:8211-24 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50396358
n/a
NameBDBM50396358
Synonyms:CHEMBL2170056
TypeSmall organic molecule
Emp. Form.C18H21Cl2N3O3
Mol. Mass.398.284
SMILESCC(=O)c1c(C)n(nc1OCCN1CCOCC1)-c1ccc(Cl)c(Cl)c1
Structure
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