Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50396358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_861906 (CHEMBL2173634) |
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Ki | 741±n/a nM |
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Citation | Díaz, JL; Cuberes, R; Berrocal, J; Contijoch, M; Christmann, U; Fernández, A; Port, A; Holenz, J; Buschmann, H; Laggner, C; Serafini, MT; Burgueño, J; Zamanillo, D; Merlos, M; Vela, JM; Almansa, C Synthesis and biological evaluation of the 1-arylpyrazole class ofs(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem55:8211-24 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50396358 |
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n/a |
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Name | BDBM50396358 |
Synonyms: | CHEMBL2170056 |
Type | Small organic molecule |
Emp. Form. | C18H21Cl2N3O3 |
Mol. Mass. | 398.284 |
SMILES | CC(=O)c1c(C)n(nc1OCCN1CCOCC1)-c1ccc(Cl)c(Cl)c1 |
Structure |
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