Reaction Details |
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Target | Macrophage migration inhibitory factor |
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Ligand | BDBM50399046 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_878772 (CHEMBL2183712) |
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Ki | 270000±n/a nM |
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Citation | Dahlgren, MK; Garcia, AB; Hare, AA; Tirado-Rives, J; Leng, L; Bucala, R; Jorgensen, WL Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor. J Med Chem55:10148-59 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage migration inhibitory factor |
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Name: | Macrophage migration inhibitory factor |
Synonyms: | GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase |
Type: | Enzyme |
Mol. Mass.: | 12478.18 |
Organism: | Homo sapiens (Human) |
Description: | P14174 |
Residue: | 115 |
Sequence: | MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALC
SLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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BDBM50399046 |
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n/a |
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Name | BDBM50399046 |
Synonyms: | CHEMBL2178862 |
Type | Small organic molecule |
Emp. Form. | C21H21NO3 |
Mol. Mass. | 335.3963 |
SMILES | COc1ccc(cc1)-c1cc(Oc2cc(C)cc(OC)c2)cc(C)n1 |
Structure |
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