| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cruzipain |
|---|
| Ligand | BDBM50330928 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_878617 (CHEMBL2189087) |
|---|
| IC50 | 400±n/a nM |
|---|
| Citation |  Moreira, DR; Costa, SP; Hernandes, MZ; Rabello, MM; de Oliveira Filho, GB; de Melo, CM; da Rocha, LF; de Simone, CA; Ferreira, RS; Fradico, JR; Meira, CS; Guimarães, ET; Srivastava, RM; Pereira, VR; Soares, MB; Leite, AC Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice. J Med Chem55:10918-36 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cruzipain |
|---|
| Name: | Cruzipain |
|---|
| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 49831.41 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | P25779 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
|
|
|
|---|
| BDBM50330928 |
|---|
| n/a |
|---|
| Name | BDBM50330928 |
|---|
| Synonyms: | 2-[(Phenylthio)propylide-1-enehydrazinyl]-5-methylthiazolidin-4-one | CHEMBL1276198 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H15N3OS2 |
|---|
| Mol. Mass. | 293.408 |
|---|
| SMILES | Cc1sc(N=NCCCSc2ccccc2)nc1O |w:4.3| |
|---|
| Structure | 
|
|---|
Search and Browse
