| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50139762 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_879256 (CHEMBL2208609) |
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| IC50 | 630±n/a nM |
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| Citation |  Marsault, E; Peterson, ML Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J Med Chem54:1961-2004 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50139762 |
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| n/a |
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| Name | BDBM50139762 |
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| Synonyms: | CHEMBL349373 | [(16R,20S)-18-((S)-Carbamoylmethyl)-14-(5-methyl-indol-1-ylmethyl)-20-(S)-oxo-8,17-dioxo-10-(4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid | [(E)-(R)-18-Carbamoylmethyl-14-(5-methyl-indol-1-ylmethyl)-8,20-dioxo-17-(S)-oxo-10-((1S,4S)-4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C38H48N5O9P |
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| Mol. Mass. | 749.7896 |
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| SMILES | Cc1ccc2n(C[C@H]3CNC(=O)[C@H](CC(N)=O)NC(=O)C4(CCCCC4)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C3)c3ccc(CP(O)(O)=O)cc3)ccc2c1 |t:36| |
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| Structure | 
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