| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50400809 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_879253 (CHEMBL2208606) |
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| IC50 | 69000±n/a nM |
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| Citation |  Marsault, E; Peterson, ML Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J Med Chem54:1961-2004 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50400809 |
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| n/a |
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| Name | BDBM50400809 |
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| Synonyms: | CHEMBL2204331 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H68N8O9 |
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| Mol. Mass. | 841.0482 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H]1COCCCCCN([C@@H](C)C(=O)N1)C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)OC |r| |
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| Structure | 
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