| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase methylesterase 1 |
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| Ligand | BDBM50400989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_879621 (CHEMBL2209153) |
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| IC50 | 4800±n/a nM |
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| Citation |  Bachovchin, DA; Zuhl, AM; Speers, AE; Wolfe, MR; Weerapana, E; Brown, SJ; Rosen, H; Cravatt, BF Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. J Med Chem54:5229-36 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase methylesterase 1 |
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| Name: | Protein phosphatase methylesterase 1 |
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| Synonyms: | PME-1 | PPME1_MOUSE | Pme1 | Ppme1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42251.88 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_879621 |
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| Residue: | 386 |
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| Sequence: | MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPVPWSQYFESMEDVEVEN
ETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKV
KNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGAIAVHTAAANLVPSLLGLCMI
DVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEG
ITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDG
WFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVA
EAVATFLIRHRFAEPIGGFQCVFPGC
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| BDBM50400989 |
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| n/a |
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| Name | BDBM50400989 |
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| Synonyms: | CHEMBL1718102 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13FN2O4S2 |
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| Mol. Mass. | 416.446 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccccc1)\C#N |
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| Structure | 
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