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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Substance-K receptor | ||
| Ligand | BDBM50299467 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_883640 (CHEMBL2210305) | ||
| Ki | 1597±n/a nM | ||
| Citation |  Bissantz, C; Bohnert, C; Hoffmann, T; Marcuz, A; Schnider, P; Malherbe, P Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonists. J Med Chem55:5061-76 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Substance-K receptor | |||
| Name: | Substance-K receptor | ||
| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 44455.78 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21452 | ||
| Residue: | 398 | ||
| Sequence: |
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| BDBM50299467 | |||
| n/a | |||
| Name | BDBM50299467 | ||
| Synonyms: | (5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidazol-5-yl)methyl)-32-amino-14,17,20-tribenzyl-5-carbamoyl-23-(carboxymethyl)-8-isobutyl-15-methyl-29-(2-(methylthio)ethyl)-7,10,13,16,19,22,25,28,31-nonaoxo-2-thia-6,9,12,15,18,21,24,27,30-nonaazatetratriacontan-34-oic acid | CHEMBL583102 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C60H81N13O14S2 | ||
| Mol. Mass. | 1272.494 | ||
| SMILES | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(N)=O |r| | ||
| Structure | 
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