| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 1 |
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| Ligand | BDBM50401542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_882149 (CHEMBL2214981) |
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| IC50 | >316227.77±n/a nM |
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| Citation |  Huynh, TH; Abrahamsen, B; Madsen, KK; Gonzalez-Franquesa, A; Jensen, AA; Bunch, L Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. Bioorg Med Chem20:6831-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 1 |
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| Name: | Excitatory amino acid transporter 1 |
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| Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59577.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
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| Residue: | 542 |
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| Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
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| BDBM50401542 |
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| n/a |
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| Name | BDBM50401542 |
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| Synonyms: | CHEMBL2207075 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H33N3O4 |
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| Mol. Mass. | 571.6649 |
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| SMILES | CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1 |c:26| |
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| Structure | 
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