| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 2 |
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| Ligand | BDBM50401545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_882148 (CHEMBL2214980) |
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| IC50 | >300000±n/a nM |
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| Citation |  Huynh, TH; Abrahamsen, B; Madsen, KK; Gonzalez-Franquesa, A; Jensen, AA; Bunch, L Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. Bioorg Med Chem20:6831-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 2 |
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| Name: | Excitatory amino acid transporter 2 |
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| Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62103.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
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| Residue: | 574 |
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| Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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| BDBM50401545 |
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| n/a |
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| Name | BDBM50401545 |
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| Synonyms: | CHEMBL2207078 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20N2O5 |
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| Mol. Mass. | 440.4474 |
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| SMILES | COc1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:22| |
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| Structure | 
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