Reaction Details |
| Report a problem with these data |
Target | Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
---|
Ligand | BDBM50403905 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_141738 (CHEMBL749250) |
---|
IC50 | 8.5±n/a nM |
---|
Citation | Tormo, JR; Estornell, E; Gallardo, T; González, MC; Cavé, A; Granell, S; Cortes, D; Zafra-Polo, MC Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. Bioorg Med Chem Lett11:681-4 (2001) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
---|
Name: | Acyl carrier protein,/NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
Synonyms: | Mitochondrial complex I; NADH oxidoreductase |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 141738 |
Components: | This complex has 2 components. |
Component 1 |
Name: | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
Synonyms: | CI-51kD | Complex I-51kD | NADH dehydrogenase flavoprotein 1 | NADH-ubiquinone oxidoreductase 51 kDa subunit | NDUFV1 | NDUV1_BOVIN | UQOR1 |
Type: | PROTEIN |
Mol. Mass.: | 50659.85 |
Organism: | Bos taurus |
Description: | EBI_100771 |
Residue: | 464 |
Sequence: | MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRG
DWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEG
EPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAG
LIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT
TVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNNPCTVEEEMSVPLKELI
EKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALIQAQTGLGTAAVIVMDRS
TDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE
GHTICALGDGAAWPVQGLIRHFRPELEERMQQFAQQHQARQAAF
|
|
|
Component 2 |
Name: | Acyl carrier protein, mitochondrial |
Synonyms: | ACP | ACPM_BOVIN | CI-SDAP | NADH-ubiquinone oxidoreductase 9.6 kDa subunit | NDUFAB1 |
Type: | PROTEIN |
Mol. Mass.: | 17397.64 |
Organism: | Bos taurus |
Description: | ChEMBL_469770 |
Residue: | 156 |
Sequence: | MAVRVLCACVRRLPTAFAPLPRLPTLAAARPLSTTLFAAETRTRPGAPLPALVLAQVPGR
VTQLCRQYSDAPPLTLEGIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIM
AMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
|
|
|
BDBM50403905 |
---|
n/a |
---|
Name | BDBM50403905 |
Synonyms: | CHEMBL608197 |
Type | Small organic molecule |
Emp. Form. | C37H68O10 |
Mol. Mass. | 672.9298 |
SMILES | CCCCCCCCCC[C@@H](O)[C@@H]1CC[C@H](O1)[C@@H](O)CC[C@H](O)[C@@H]1CC[C@@H](CCCCCCC[C@@H](O)C[C@@]2(O)[C@H](O)[C@@H](C)OC2=O)O1 |r| |
Structure |
|