| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM1099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_36514 |
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| Ki | 230±n/a nM |
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| Citation |  Katritzky, AR; Oliferenko, A; Lomaka, A; Karelson, M Six-membered cyclic ureas as HIV-1 protease inhibitors: a QSAR study based on CODESSA PRO approach. Quantitative structure-activity relationships. Bioorg Med Chem Lett12:3453-7 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
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|
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| BDBM1099 |
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| n/a |
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| Name | BDBM1099 |
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| Synonyms: | (4R,5R,6R)-Tetrahydro-1,3-bis[(3-cyano-4-fluorophenyl)methyl]-5-hydroxy-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone | 5-{[(4R,5R,6R)-4-benzyl-3-[(3-cyano-4-fluorophenyl)methyl]-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]methyl}-2-fluorobenzonitrile | Tetrahydropyrimidinone deriv. 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H30F2N4O2 |
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| Mol. Mass. | 576.6351 |
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| SMILES | O[C@@H]1[C@@H](CCc2ccccc2)N(Cc2ccc(F)c(c2)C#N)C(=O)N(Cc2ccc(F)c(c2)C#N)[C@@H]1Cc1ccccc1 |r| |
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| Structure | 
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