Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50405038 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53616 (CHEMBL661845) |
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Ki | 28±n/a nM |
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Citation | Hansch, C; Hathaway, BA; Guo, ZR; Selassie, CD; Dietrich, SW; Blaney, JM; Langridge, R; Volz, KW; Kaufman, BT Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. J Med Chem27:129-43 (1984) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | 1.5.1.3 | DHFR | DYR_CHICK |
Type: | n/a |
Mol. Mass.: | 21652.69 |
Organism: | Gallus gallus (Chicken) |
Description: | n/a |
Residue: | 189 |
Sequence: | VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSI
PEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAV
YKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFE
VYQKSVLAQ
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BDBM50405038 |
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n/a |
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Name | BDBM50405038 |
Synonyms: | CHEMBL33697 |
Type | Small organic molecule |
Emp. Form. | C21H24Cl2FN5O2S |
Mol. Mass. | 500.417 |
SMILES | CC1(C)N=C(N)N=C(N)N1c1ccc(CCCCc2ccc(cc2Cl)S(F)(=O)=O)c(Cl)c1 |t:3,6| |
Structure |
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