| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
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| Ligand | BDBM50406084 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_59428 (CHEMBL671831) |
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| IC50 | 173780.08±n/a nM |
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| Citation |  So, SS; Karplus, M Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications. J Med Chem40:4360-71 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dopamine beta-hydroxylase |
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| Name: | Dopamine beta-hydroxylase |
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| Synonyms: | DBH | DOPO_HUMAN | Dopamine beta-monooxygenase | Soluble dopamine beta-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69062.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_59428 |
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| Residue: | 617 |
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| Sequence: | MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYHIPLDPEGSLE
LSWNVSYTQEAIHFQLLVRRLKAGVLFGMSDRGELENADLVVLWTDGDTAYFADAWSDQK
GQIHLDPQQDYQLLQVQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSL
EAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKG
FSRHHIIKYEPIVTKGNEALVHHMEVFQCAPEMDSVPHFSGPCDSKMKPDRLNYCRHVLA
AWALGAKAFYYPEEAGLAFGGPGSSRYLRLEVHYHNPLVIEGRNDSSGIRLYYTAKLRRF
NAGIMELGLVYTPVMAIPPRETAFILTGYCTDKCTQLALPPSGIHIFASQLHTHLTGRKV
VTVLVRDGREWEIVNQDNHYSPHFQEIRMLKKVVSVHPGDVLITSCTYNTEDRELATVGG
FGILEEMCVNYVHYYPQTQLELCKSAVDAGFLQKYFHLINRFNNEDVCTCPQASVSQQFT
SVPWNSFNRDVLKALYSFAPISMHCNKSSAVRFQGEWNLQPLPKVISTLEEPTPQCPTSQ
GRSPAGPTVVSIGGGKG
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| BDBM50406084 |
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| n/a |
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| Name | BDBM50406084 |
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| Synonyms: | CHEMBL67213 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11F3N2OS |
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| Mol. Mass. | 288.289 |
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| SMILES | COc1ccc(Cn2cc[nH]c2=S)cc1C(F)(F)F |
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| Structure | 
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