| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin reductase 1 |
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| Ligand | BDBM50410834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_341692 (CHEMBL861403) |
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| IC50 | 1420±n/a nM |
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| Citation |  Gong, J; Neels, JF; Yu, X; Kensler, TW; Peterson, LA; Sturla, SJ Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. J Med Chem49:2593-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin reductase 1 |
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| Name: | Prostaglandin reductase 1 |
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| Synonyms: | Dig1 | Ltb4dh | NADP-dependent leukotriene B4 12-hydroxydehydrogenase | PTGR1_RAT | Ptgr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35721.48 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_341692 |
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| Residue: | 329 |
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| Sequence: | MVQAKTWTLKKHFEGFPTDSNFELRTTELPPLNNGEVLLEALFLSVDPYMRVAAKKLKEG
DSMMGEQVARVVESKNSAFPTGTIVVALLGWTSHSISDGNGLRKLPAEWPDKLPLSLALG
TVGMPGLTAYFGLLDICGLKGGETVLVNAAAGAVGSVVGQIAKLKGCKVVGTAGSDEKVA
YLKKLGFDVAFNYKTVKSLEEALRTASPDGYDCYFDNVGGEFSNTVILQMKTFGRIAICG
AISQYNRTGPCPPGPSPEVIIYQQLRMEGFIVTRWQGEVRQKALTDLMNWVSEGKIRYHE
YITEGFEKMPAAFMGMLKGDNLGKTIVKA
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| BDBM50410834 |
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| n/a |
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| Name | BDBM50410834 |
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| Synonyms: | CHEMBL380919 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18O3 |
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| Mol. Mass. | 246.3016 |
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| SMILES | CC1=C(CO)C2=C(C)C3(CC3)[C@](C)(O)C(=O)C2=C1 |c:1,5,18| |
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| Structure | 
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