Reaction Details |
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Target | Alpha-1D adrenergic receptor |
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Ligand | BDBM50412773 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_539782 (CHEMBL1035000) |
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Ki | 43.65±n/a nM |
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Citation | Quaglia, W; Piergentili, A; Del Bello, F; Farande, Y; Giannella, M; Pigini, M; Rafaiani, G; Carrieri, A; Amantini, C; Lucciarini, R; Santoni, G; Poggesi, E; Leonardi, A Structure-activity relationships in 1,4-benzodioxan-related compounds. 9. From 1,4-benzodioxane to 1,4-dioxane ring as a promising template of novel alpha1D-adrenoreceptor antagonists, 5-HT1A full agonists, and cytotoxic agents. J Med Chem51:6359-70 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1D adrenergic receptor |
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Name: | Alpha-1D adrenergic receptor |
Synonyms: | ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 60485.82 |
Organism: | Homo sapiens (Human) |
Description: | adrenergic Alpha1D ADRA1D HUMAN::P25100 |
Residue: | 572 |
Sequence: | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
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BDBM50412773 |
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n/a |
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Name | BDBM50412773 |
Synonyms: | CHEMBL452437 |
Type | Small organic molecule |
Emp. Form. | C20H25NO4 |
Mol. Mass. | 343.4168 |
SMILES | COc1ccccc1OCCNC[C@@H]1COC[C@@H](O1)c1ccccc1 |r| |
Structure |
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