Reaction Details | |||
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Target | D(2) dopamine receptor | ||
Ligand | BDBM50414555 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_582204 (CHEMBL1059864) | ||
Ki | 25.12±n/a nM | ||
Citation | Holmes, IP; Micheli, F; Gaines, S; Lorthioir, O; Watson, SP; Fabio, RD; Gentile, G; Heidbreder, C; Savoia, C; Worby, A Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. Bioorg Med Chem Lett19:4799-801 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
D(2) dopamine receptor | |||
Name: | D(2) dopamine receptor | ||
Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 | ||
Type: | Cell-surface receptors | ||
Mol. Mass.: | 50647.10 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P14416 | ||
Residue: | 443 | ||
Sequence: |
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BDBM50414555 | |||
n/a | |||
Name | BDBM50414555 | ||
Synonyms: | CHEMBL565075 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H26ClN3O | ||
Mol. Mass. | 347.882 | ||
SMILES | Clc1cccc(c1)N1CCN(CCN2C[C@H]3CC[C@H](CC3)C2)C1=O |r,wD:15.21,18.19,(12.76,-.71,;12.72,-2.25,;11.37,-2.98,;11.33,-4.53,;12.64,-5.34,;14,-4.6,;14.04,-3.05,;15.44,-5.15,;15.87,-6.63,;17.41,-6.67,;17.92,-5.22,;19.25,-4.44,;20.59,-5.2,;21.92,-4.42,;22.75,-2.96,;24.43,-2.94,;25.71,-3.64,;25.72,-5.11,;24.45,-5.86,;23.16,-5.16,;23.15,-3.69,;22.77,-5.87,;16.7,-4.28,;16.74,-2.74,)| | ||
Structure |