| Reaction Details |
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 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
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| Ligand | BDBM50415790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_625092 (CHEMBL1112541) |
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| EC50 | >19952.62±n/a nM |
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| Citation |  Rimland, J; Dunne, A; Hunjan, SS; Sasse, R; Uings, I; Montanari, D; Caivano, M; Shah, P; Standing, D; Gray, D; Brown, D; Cairns, W; Trump, R; Smith, PW; Bertheleme, N; D'Alessandro, P; Gul, S; Vimal, M; Smith, DN; Watson, SP The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Bioorg Med Chem Lett20:2340-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mineralocorticoid receptor |
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| Name: | Mineralocorticoid receptor |
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| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 107076.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08235 |
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| Residue: | 984 |
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| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
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| BDBM50415790 |
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| n/a |
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| Name | BDBM50415790 |
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| Synonyms: | CHEMBL1093774 | GSK-1564023A | US10272074, Example 115 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20ClN5O2 |
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| Mol. Mass. | 409.869 |
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| SMILES | Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1 |
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| Structure | 
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