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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417512 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 25.12±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50417512 | |||
| n/a | |||
| Name | BDBM50417512 | ||
| Synonyms: | CHEMBL1287878 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H24N6O2 | ||
| Mol. Mass. | 392.4543 | ||
| SMILES | COc1ccc(-c2c(C)nn3c(NC(C)c4nc(C)no4)cc(C)nc23)c(C)c1 |(24.98,-32.53,;23.44,-32.51,;22.69,-31.16,;21.15,-31.13,;20.4,-29.81,;21.19,-28.48,;20.43,-27.14,;21.39,-25.94,;22.92,-25.99,;20.53,-24.65,;19.05,-25.07,;17.75,-24.25,;17.81,-22.71,;16.5,-21.89,;16.55,-20.36,;15.25,-22.79,;13.79,-22.31,;12.88,-23.53,;11.34,-23.53,;13.77,-24.79,;15.25,-24.33,;16.37,-24.97,;16.32,-26.51,;14.96,-27.23,;17.63,-27.33,;18.99,-26.61,;22.73,-28.5,;23.51,-27.18,;23.48,-29.85,)| | ||
| Structure | 
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