| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 1 |
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| Ligand | BDBM50033369 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_836456 (CHEMBL2076896) |
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| IC50 | 76300±n/a nM |
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| Citation |  Ishiguro, N; Saito, A; Yokoyama, K; Morikawa, M; Igarashi, T; Tamai, I Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos33:495-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 1 |
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| Name: | Solute carrier family 22 member 1 |
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| Synonyms: | Adrenaline alpha1 | Oct1 | Organic cation transporter 1 | S22A1_RAT | Slc22a1 | Solute carrier family 22 member 1 | adrenergic Alpha1 | rOCT1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 61538.40 |
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| Organism: | RAT |
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| Description: | Adrenaline alpha1 0 RAT::Q63089 |
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| Residue: | 556 |
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| Sequence: | MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQ
RCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLG
PCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCL
LVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAIL
YQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAV
RIMEQIAQKNGKVPPADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAV
LYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLL
MIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIF
TPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAK
ENTIYLQVQTGKSSST
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| BDBM50033369 |
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| n/a |
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| Name | BDBM50033369 |
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| Synonyms: | AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL |
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| Type | Small organic molecule |
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| Emp. Form. | C10H17N |
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| Mol. Mass. | 151.2487 |
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| SMILES | NC12CC3CC(CC(C3)C1)C2 |THB:6:5:2:8.7.9,6:7:4.5.10:2,9:7:4:10.1.2,9:1:4:8.6.7,0:1:4:8.6.7| |
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| Structure | 
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