| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50424530 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_937727 (CHEMBL2317477) |
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| IC50 | >1000±n/a nM |
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| Citation |  Khan, PM; El-Gendy, Bel-D; Kumar, N; Garcia-Ordonez, R; Lin, L; Ruiz, CH; Cameron, MD; Griffin, PR; Kamenecka, TM Small molecule amides as potent ROR-¿ selective modulators. Bioorg Med Chem Lett23:532-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50424530 |
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| n/a |
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| Name | BDBM50424530 |
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| Synonyms: | CHEMBL2312122 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26F3NO6 |
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| Mol. Mass. | 481.4615 |
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| SMILES | COc1cc(O)c(C(CC(=O)N2CCCC(C2)C(F)(F)F)c2ccc3OCOc3c2)c(OC)c1 |
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| Structure | 
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