Reaction Details |
| Report a problem with these data |
Target | NEDD8-activating enzyme E1 regulatory subunit |
---|
Ligand | BDBM50427034 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_939694 (CHEMBL2328919) |
---|
IC50 | 4.7±n/a nM |
---|
Citation | da Silva, SR; Paiva, SL; Lukkarila, JL; Gunning, PT Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes. J Med Chem56:2165-77 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NEDD8-activating enzyme E1 regulatory subunit |
---|
Name: | NEDD8-activating enzyme E1 regulatory subunit |
Synonyms: | APP-BP1 | APPBP1 | Amyloid beta precursor protein-binding protein 1, 59 kDa | Amyloid protein-binding protein 1 | NAE1 | Proto-oncogene protein 1 | ULA1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 60233.54 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_939705 |
Residue: | 534 |
Sequence: | MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
|
|
|
BDBM50427034 |
---|
n/a |
---|
Name | BDBM50427034 |
Synonyms: | CHEMBL2322194 |
Type | Small organic molecule |
Emp. Form. | C21H27N5O4S |
Mol. Mass. | 445.535 |
SMILES | NS(=O)(=O)OC[C@@H]1C[C@H](C[C@@H]1O)N1CCc2c1ncnc2N[C@H]1CCc2ccccc12 |r| |
Structure |
|