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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent betaine transporter | ||
| Ligand | BDBM50343258 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_941203 (CHEMBL2329714) | ||
| IC50 | 2000±n/a nM | ||
| Citation |  Vogensen, SB; Jørgensen, L; Madsen, KK; Borkar, N; Wellendorph, P; Skovgaard-Petersen, J; Schousboe, A; White, HS; Krogsgaard-Larsen, P; Clausen, RP Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. J Med Chem56:2160-4 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent betaine transporter | |||
| Name: | Sodium- and chloride-dependent betaine transporter | ||
| Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 69615.88 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_1460088 | ||
| Residue: | 614 | ||
| Sequence: |
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| BDBM50343258 | |||
| n/a | |||
| Name | BDBM50343258 | ||
| Synonyms: | 4-((4,4-bis(3-methylthiophen-2-yl)but-3-enyl)(methyl)amino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol | CHEMBL1773934 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N2O2S2 | ||
| Mol. Mass. | 414.584 | ||
| SMILES | CN(CCC=C(c1sccc1C)c1sccc1C)C1CCCc2o[nH]c(=O)c12 |(14.45,-29.58,;13.12,-28.81,;11.79,-29.58,;11.79,-31.12,;10.46,-31.89,;10.46,-33.43,;9.2,-34.32,;7.74,-33.83,;6.83,-35.07,;7.71,-36.32,;9.18,-35.86,;10.42,-36.78,;11.86,-34.07,;12.17,-35.57,;13.69,-35.75,;14.34,-34.35,;13.2,-33.31,;13.38,-31.78,;13.12,-27.27,;14.45,-26.5,;14.45,-24.97,;13.12,-24.2,;11.77,-24.97,;10.3,-24.49,;9.4,-25.74,;10.31,-26.99,;9.83,-28.46,;11.78,-26.51,)| | ||
| Structure | 
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