Ki Summary

Reaction Details

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Target

Sialidase-4

Ligand

BDBM50063303

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_941546 (CHEMBL2330586)

IC50

720000±n/a nM

Citation

Zhang, Y; Albohy, A; Zou, Y; Smutova, V; Pshezhetsky, AV; Cairo, CW Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. J Med Chem56:2948-58 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sialidase-4

Name:

Sialidase-4

Synonyms:

NEU4 | NEUR4_HUMAN | Sialidase 4

Type:

PROTEIN

Mol. Mass.:

51579.82

Organism:

Homo sapiens (Human)

Description:

ChEMBL_960637

Residue:

484

Sequence:

MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGT
LAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRN
AARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYR
VDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCN
ARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGP
GSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSW
TLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYS
DLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGC
CWPS

BDBM50063303

n/a

Name

BDBM50063303

Synonyms:

(2R,3R,4S)-3-acetamido-4-amino-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid | (4S,5R,6R)-5-Acetylamino-4-amino-6-((1R,2R)-1,2,3-trihydroxy-propyl)-5,6-dihydro-4H-pyran-2-carboxylic acid | (4S,5R,6R)-5-acetamido-4-amino-6-((1R,2R)-1,2,3-trihydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid | 4-AMINO-2-DEOXY-2,3-DEHYDRO-N-NEURAMINIC ACID | CHEMBL52270

Type

Small organic molecule

Emp. Form.

C11H18N2O7

Mol. Mass.

290.2698

SMILES

CC(=O)N[C@@H]1[C@@H](N)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r,c:7|

Structure