Ki Summary

Reaction Details

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Target

Sodium-dependent dopamine transporter

Ligand

BDBM50428498

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_943962 (CHEMBL2340406)

10900±n/a nM

Citation

Zhang, P; Jørgensen, TN; Loland, CJ; Newman, AH A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter. Bioorg Med Chem Lett23:323-6 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sodium-dependent dopamine transporter

Name:

Sodium-dependent dopamine transporter

Synonyms:

Type:

Multi-pass membrane protein

Mol. Mass.:

68497.11

Organism:

Homo sapiens (Human)

Description:

Q01959

Residue:

620

Sequence:

MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV

BDBM50428498

n/a

Name

BDBM50428498

Synonyms:

CHEMBL2336610

Type

Small organic molecule

Emp. Form.

C61H71FN6O9S2

Mol. Mass.

1115.38

SMILES

CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCC(=O)Nc3cccc(c3)-c3ccc4c(COC4(CCCN(C)C)c4ccc(F)cc4)c3)c3ccc(cc3oc2c1)=[N+](CC)CC |(19.16,-47.15,;19.13,-48.69,;20.44,-49.49,;20.41,-51.03,;21.72,-51.83,;21.79,-48.75,;23.12,-49.55,;24.48,-48.8,;24.5,-47.26,;25.84,-46.5,;27.16,-47.29,;27.14,-48.84,;28.46,-49.62,;29.8,-48.87,;29.83,-47.33,;28.51,-46.54,;28.53,-45,;29.88,-44.25,;28.13,-43.51,;27.02,-45.39,;31.12,-49.66,;30.34,-51,;31.88,-51.02,;32.47,-48.91,;33.79,-49.7,;35.14,-48.95,;36.46,-49.74,;37.8,-48.99,;39.12,-49.78,;40.47,-49.03,;40.49,-47.49,;41.79,-49.82,;43.14,-49.07,;44.46,-49.86,;45.8,-49.11,;45.83,-47.57,;47.13,-49.92,;48.46,-49.15,;48.46,-47.6,;49.79,-46.83,;51.12,-47.6,;51.12,-49.15,;49.79,-49.91,;52.45,-49.91,;53.78,-49.15,;55.12,-49.92,;55.11,-51.46,;53.78,-52.23,;54.1,-53.73,;55.63,-53.89,;56.26,-52.49,;57.02,-51.15,;58.56,-51.14,;59.32,-49.8,;60.87,-49.79,;61.63,-48.46,;61.64,-51.12,;57.59,-53.26,;58.93,-52.49,;60.26,-53.26,;60.25,-54.8,;61.59,-55.57,;58.92,-55.57,;57.59,-54.8,;52.45,-51.45,;25.87,-44.97,;27.21,-44.23,;27.25,-42.69,;25.93,-41.9,;24.58,-42.64,;24.55,-44.17,;23.2,-44.92,;23.18,-46.45,;21.83,-47.2,;25.96,-40.36,;27.31,-39.61,;28.63,-40.41,;24.65,-39.56,;23.3,-40.31,)|

Structure