| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage metalloelastase |
|---|
| Ligand | BDBM50429232 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_946628 (CHEMBL2342136) |
|---|
| IC50 | 2300±n/a nM |
|---|
| Citation |  Yuan, H; Lu, W; Wang, L; Shan, L; Li, H; Huang, J; Sun, Q; Zhang, W Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1). Eur J Med Chem62:148-57 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage metalloelastase |
|---|
| Name: | Macrophage metalloelastase |
|---|
| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54012.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P39900 |
|---|
| Residue: | 470 |
|---|
| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
|---|
| BDBM50429232 |
|---|
| n/a |
|---|
| Name | BDBM50429232 |
|---|
| Synonyms: | CHEMBL2333288 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H32O8 |
|---|
| Mol. Mass. | 568.6131 |
|---|
| SMILES | COc1ccc(C[C@H](OC(=O)\C=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C(O)=O)cc1OC |r| |
|---|
| Structure | 
|
|---|
Search and Browse
