| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 6 |
|---|
| Ligand | BDBM50056272 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_958949 (CHEMBL2382646) |
|---|
| EC50 | 3360±n/a nM |
|---|
| Citation |  Monn, JA; Valli, MJ; Massey, SM; Hao, J; Reinhard, MR; Bures, MG; Heinz, BA; Wang, X; Carter, JH; Getman, BG; Stephenson, GA; Herin, M; Catlow, JT; Swanson, S; Johnson, BG; McKinzie, DL; Henry, SS Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. J Med Chem56:4442-55 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 6 |
|---|
| Name: | Metabotropic glutamate receptor 6 |
|---|
| Synonyms: | GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 95479.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | metabotropic glutamate 6 GRM6 HUMAN::O15303 |
|---|
| Residue: | 877 |
|---|
| Sequence: | MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
|
|
|
|---|
| BDBM50056272 |
|---|
| n/a |
|---|
| Name | BDBM50056272 |
|---|
| Synonyms: | (1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid | (2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY 354740) | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(LY354740) | CHEMBL8759 | LY-354740 | LY366563 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H11NO4 |
|---|
| Mol. Mass. | 185.1772 |
|---|
| SMILES | N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
