| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50434818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_962701 (CHEMBL2388428) |
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| IC50 | 1610±n/a nM |
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| Citation |  Cao, SL; Han, Y; Yuan, CZ; Wang, Y; Xiahou, ZK; Liao, J; Gao, RT; Mao, BB; Zhao, BL; Li, ZF; Xu, X Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline. Eur J Med Chem64:401-9 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50434818 |
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| n/a |
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| Name | BDBM50434818 |
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| Synonyms: | CHEMBL2387094 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N7O2S2 |
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| Mol. Mass. | 455.556 |
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| SMILES | Nc1nc(N)c2cc(CSC(=S)N3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)ccc2n1 |
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| Structure | 
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