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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM50435517 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_966072 (CHEMBL2395113) | ||
| Ki | 120±n/a nM | ||
| Citation |  Hurley, CA; Blair, WS; Bull, RJ; Chang, C; Crackett, PH; Deshmukh, G; Dyke, HJ; Fong, R; Ghilardi, N; Gibbons, P; Hewitt, PR; Johnson, A; Johnson, T; Kenny, JR; Kohli, PB; Kulagowski, JJ; Liimatta, M; Lupardus, PJ; Maxey, RJ; Mendonca, R; Narukulla, R; Pulk, R; Ubhayakar, S; van Abbema, A; Ward, SI; Waszkowycz, B; Zak, M Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1. Bioorg Med Chem Lett23:3592-8 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM50435517 | |||
| n/a | |||
| Name | BDBM50435517 | ||
| Synonyms: | CHEMBL2392482 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H24N6O2 | ||
| Mol. Mass. | 356.4222 | ||
| SMILES | CC(C)(C)OC(=O)N[C@H]1CC[C@@H](CC1)n1nnc2cnc3[nH]ccc3c12 |r,wU:8.7,wD:11.14,(38.37,-38.93,;38.33,-37.4,;39.64,-36.59,;39.65,-38.16,;36.97,-36.66,;35.66,-37.47,;35.7,-39.01,;34.31,-36.73,;33,-37.54,;33.04,-39.08,;31.73,-39.88,;30.37,-39.15,;30.32,-37.61,;31.64,-36.8,;29.07,-39.95,;27.55,-39.8,;26.93,-41.21,;28.08,-42.22,;28.08,-43.77,;29.41,-44.54,;30.75,-43.76,;32.22,-44.23,;33.12,-42.97,;32.2,-41.73,;30.74,-42.22,;29.4,-41.45,)| | ||
| Structure | 
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