Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1

Ligand

BDBM50435522

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_966072 (CHEMBL2395113)

5.9±n/a nM

Citation

Hurley, CA; Blair, WS; Bull, RJ; Chang, C; Crackett, PH; Deshmukh, G; Dyke, HJ; Fong, R; Ghilardi, N; Gibbons, P; Hewitt, PR; Johnson, A; Johnson, T; Kenny, JR; Kohli, PB; Kulagowski, JJ; Liimatta, M; Lupardus, PJ; Maxey, RJ; Mendonca, R; Narukulla, R; Pulk, R; Ubhayakar, S; van Abbema, A; Ward, SI; Waszkowycz, B; Zak, M Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1. Bioorg Med Chem Lett23:3592-8 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1

Name:

Tyrosine-protein kinase JAK1

Synonyms:

Type:

Protein

Mol. Mass.:

133293.73

Organism:

Homo sapiens (Human)

Description:

P23458

Residue:

1154

Sequence:

MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK

BDBM50435522

n/a

Name

BDBM50435522

Synonyms:

CHEMBL2392480

Type

Small organic molecule

Emp. Form.

C16H19N7

Mol. Mass.

309.369

SMILES

N#CCCN[C@H]1CC[C@@H](CC1)n1nnc2cnc3[nH]ccc3c12 |r,wU:5.4,wD:8.11,(11.59,-36.36,;10.24,-35.63,;8.89,-34.9,;7.58,-35.71,;6.22,-34.97,;4.91,-35.78,;4.95,-37.32,;3.65,-38.12,;2.29,-37.39,;2.24,-35.85,;3.56,-35.04,;.99,-38.19,;-.54,-38.04,;-1.15,-39.44,;-.01,-40.46,;-.01,-42,;1.33,-42.77,;2.67,-41.99,;4.14,-42.46,;5.04,-41.21,;4.12,-39.97,;2.66,-40.45,;1.32,-39.68,)|

Structure