Reaction Details |
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Target | Glutaminyl-peptide cyclotransferase |
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Ligand | BDBM50435529 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_966260 (CHEMBL2395921) |
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IC50 | 375±n/a nM |
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Citation | Tran, PT; Hoang, VH; Thorat, SA; Kim, SE; Ann, J; Chang, YJ; Nam, DW; Song, H; Mook-Jung, I; Lee, J; Lee, J Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template. Bioorg Med Chem21:3821-30 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminyl-peptide cyclotransferase |
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Name: | Glutaminyl-peptide cyclotransferase |
Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 40877.05 |
Organism: | Homo sapiens (Human) |
Description: | Q16769 |
Residue: | 361 |
Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
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BDBM50435529 |
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n/a |
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Name | BDBM50435529 |
Synonyms: | CHEMBL2392783 |
Type | Small organic molecule |
Emp. Form. | C17H19N5S |
Mol. Mass. | 325.431 |
SMILES | Cc1cncn1CCCNC(=S)Nc1cccc2ncccc12 |
Structure |
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