Reaction Details | |||
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Target | Lysine-specific demethylase 6B | ||
Ligand | BDBM50436040 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_964444 (CHEMBL2396333) | ||
IC50 | 9500±n/a nM | ||
Citation | Xu, W; Podoll, JD; Dong, X; Tumber, A; Oppermann, U; Wang, X Quantitative analysis of histone demethylase probes using fluorescence polarization. J Med Chem56:5198-202 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Lysine-specific demethylase 6B | |||
Name: | Lysine-specific demethylase 6B | ||
Synonyms: | JMJD3 | JmjC domain-containing protein 3 | Jumonji domain-containing protein 3 | KDM6B | KDM6B_HUMAN | KIAA0346 | Lysine demethylase 6B | Lysine-specific demethylase 6B | Lysine-specific demethylase 6B (KDM6B(JMJD3)) | Lysine-specific demethylase 6B (KDM6B) | ||
Type: | Protein | ||
Mol. Mass.: | 176672.55 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O15054 | ||
Residue: | 1643 | ||
Sequence: |
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BDBM50436040 | |||
n/a | |||
Name | BDBM50436040 | ||
Synonyms: | CHEMBL2392184 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H32N4O9S | ||
Mol. Mass. | 708.737 | ||
SMILES | NCc1ccc(CN(CCCCN(O)C(=O)C=CC([O-])=O)C(=S)Nc2ccc(c(c2)C([O-])=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)cc1 |w:16.15,(37.34,-10.75,;37.34,-12.29,;36.01,-13.06,;36.02,-14.61,;34.68,-15.38,;33.36,-14.6,;32.02,-15.38,;30.69,-14.61,;29.36,-15.38,;29.36,-16.92,;28.03,-17.7,;26.69,-16.93,;25.36,-17.7,;25.36,-19.24,;24.03,-16.94,;24.02,-15.4,;22.69,-17.71,;21.36,-16.94,;20.03,-17.71,;18.69,-16.95,;20.03,-19.25,;30.69,-13.07,;32.02,-12.3,;29.35,-12.3,;29.35,-10.76,;28.01,-9.99,;28.01,-8.45,;29.35,-7.68,;30.68,-8.45,;30.68,-9.98,;32.01,-7.67,;33.34,-8.44,;33.1,-6.57,;29.34,-6.15,;30.67,-5.38,;32,-6.15,;33.34,-5.38,;33.33,-3.84,;34.66,-3.06,;32,-3.07,;30.68,-3.84,;29.34,-3.07,;28.01,-3.84,;26.69,-3.06,;25.36,-3.84,;24.02,-3.08,;25.36,-5.38,;26.69,-6.14,;28.02,-5.38,;33.34,-13.07,;34.67,-12.3,)| | ||
Structure |