| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50436213 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_966382 (CHEMBL2401601) |
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| IC50 | 39811±n/a nM |
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| Citation |  Naumann, EC; Göring, S; Ogorek, I; Weggen, S; Schmidt, B Membrane anchoring¿-secretase modulators with terpene-derived moieties. Bioorg Med Chem Lett23:3852-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50436213 |
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| n/a |
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| Name | BDBM50436213 |
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| Synonyms: | CHEMBL2396675 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H56O4 |
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| Mol. Mass. | 528.806 |
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| SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\COc1c(C)c(C)c2OC(C)(CCc2c1C)C(O)=O |r| |
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| Structure | 
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