Reaction Details |
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Target | Chymase |
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Ligand | BDBM50436407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_967547 (CHEMBL2398941) |
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IC50 | 770±n/a nM |
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Citation | Tanaka, T; Sugawara, H; Maruoka, H; Imajo, S; Muto, T Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design. Bioorg Med Chem21:4233-49 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chymase |
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Name: | Chymase |
Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
Type: | Enzyme |
Mol. Mass.: | 27340.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 247 |
Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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BDBM50436407 |
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n/a |
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Name | BDBM50436407 |
Synonyms: | CHEMBL2396996 |
Type | Small organic molecule |
Emp. Form. | C25H27ClN4O7 |
Mol. Mass. | 530.957 |
SMILES | CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1ccc(cc1)C(O)=O |r| |
Structure |
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