| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Orexin receptor type 2 |
|---|
| Ligand | BDBM50434481 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_977032 (CHEMBL2416556) |
|---|
| Ki | 1.1±n/a nM |
|---|
| Citation |  Lebold, TP; Bonaventure, P; Shireman, BT Selective orexin receptor antagonists. Bioorg Med Chem Lett23:4761-9 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Orexin receptor type 2 |
|---|
| Name: | Orexin receptor type 2 |
|---|
| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50710.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43614 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
|
|
|
|---|
| BDBM50434481 |
|---|
| n/a |
|---|
| Name | BDBM50434481 |
|---|
| Synonyms: | CHEMBL2385132 | CHEMBL2385133 | CHEMBL2385134 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26N4O4S |
|---|
| Mol. Mass. | 454.542 |
|---|
| SMILES | CCN(Cc1cccnc1)C(=O)CN(c1ccc(OC)nc1)S(=O)(=O)c1ccccc1C |
|---|
| Structure | 
|
|---|
Search and Browse
