Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | ATP-dependent DNA helicase Q1 |
---|
Ligand | BDBM50440527 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_983200 (CHEMBL2428259) |
---|
IC50 | >50000±n/a nM |
---|
Citation | Rosenthal, AS; Dexheimer, TS; Gileadi, O; Nguyen, GH; Chu, WK; Hickson, ID; Jadhav, A; Simeonov, A; Maloney, DJ Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorg Med Chem Lett23:5660-6 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
ATP-dependent DNA helicase Q1 |
---|
Name: | ATP-dependent DNA helicase Q1 |
Synonyms: | DNA helicase, RecQ-like type 1 | DNA-dependent ATPase Q1 | RECQ1 | RECQ1_HUMAN | RECQL | RECQL1 | RecQ protein-like 1 |
Type: | PROTEIN |
Mol. Mass.: | 73468.16 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_103669 |
Residue: | 649 |
Sequence: | MASVSALTEELDSITSELHAVEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNE
YDSSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKS
LCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNK
NSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGI
LKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDF
IEDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKW
SANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGF
GDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQHFDEVWNSEACNKMCDNCCK
DSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTLPRE
DLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNSFRA
ESSQTCHSEQGDKKMEEKNSGNFQKKAANMLQQSGSKNTGAKKRKIDDA
|
|
|
BDBM50440527 |
---|
n/a |
---|
Name | BDBM50440527 |
Synonyms: | CHEMBL2426164 |
Type | Small organic molecule |
Emp. Form. | C15H9BrN6OS |
Mol. Mass. | 401.241 |
SMILES | Brc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C#N |
Structure |
|