| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 2 |
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| Ligand | BDBM50241049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_984145 (CHEMBL2432073) |
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| IC50 | 14±n/a nM |
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| Citation |  Yau, MK; Liu, L; Fairlie, DP Toward drugs for protease-activated receptor 2 (PAR2). J Med Chem56:7477-97 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 2 |
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| Name: | Proteinase-activated receptor 2 |
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| Synonyms: | F2RL1 | GPR11 | PAR2 | PAR2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44152.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497756 |
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| Residue: | 397 |
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| Sequence: | MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFS
VDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALA
DLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNP
MGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMF
NYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICF
TPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALL
CRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
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| BDBM50241049 |
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| n/a |
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| Name | BDBM50241049 |
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| Synonyms: | CHEMBL463763 | Triptolide, 1 | triptolide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24O6 |
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| Mol. Mass. | 360.401 |
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| SMILES | CC(C)[C@]12O[C@H]1[C@@H]1O[C@]11[C@]3(O[C@H]3C[C@H]3C4=C(CC[C@]13C)C(=O)OC4)[C@@H]2O |r,c:17| |
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| Structure | 
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