Reaction Details |
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Target | Heme oxygenase 1 |
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Ligand | BDBM50441453 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_988012 (CHEMBL2438670) |
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IC50 | >100000±n/a nM |
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Citation | Vlahakis, JZ; Vukomanovic, D; Nakatsu, K; Szarek, WA Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position. Bioorg Med Chem21:6788-95 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heme oxygenase 1 |
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Name: | Heme oxygenase 1 |
Synonyms: | HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1 |
Type: | Enzyme |
Mol. Mass.: | 33005.15 |
Organism: | Rattus norvegicus (rat) |
Description: | HO-1 obtained from rat spleen was used in enzyme assays. |
Residue: | 289 |
Sequence: | MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTA
LEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHE
VGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQ
LYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRP
ASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
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BDBM50441453 |
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n/a |
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Name | BDBM50441453 |
Synonyms: | CHEMBL2436290 |
Type | Small organic molecule |
Emp. Form. | C19H20N4O2 |
Mol. Mass. | 336.3877 |
SMILES | [O-][N+](=O)c1cccc(Cn2c(CN3CCCC3)nc3ccccc23)c1 |
Structure |
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