| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50448050 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1289501 (CHEMBL3117417) |
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| IC50 | 100±n/a nM |
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| Citation |  El-Subbagh, HI; Hassan, GS; El-Messery, SM; Al-Rashood, ST; Al-Omary, FA; Abulfadl, YS; Shabayek, MI Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: synthesis, antitumor testing and molecular modeling study. Eur J Med Chem74:234-45 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 21603.71 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P00376 |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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| BDBM50448050 |
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| n/a |
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| Name | BDBM50448050 |
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| Synonyms: | CHEMBL3115742 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H18Br2Cl2N2 |
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| Mol. Mass. | 589.149 |
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| SMILES | Clc1cc2N=C3C(CCCC3=Cc3ccc(Br)cc3)C(=Nc2cc1Cl)c1ccc(Br)cc1 |w:11.12,c:4,21| |
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| Structure | 
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